Hemoglobin: Some (Dis)Assembly Required

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly

The vacuolar protein sorting 4 AAA-ATPase (Vps4) recycles endosomal sorting complexes required for transport (ESCRT-III) polymers from cellular membranes. Here we present a 3.6-Å X-ray structure of ring-shaped Vps4 from Metallosphera sedula (MsVps4), seen as an asymmetric pseudohexamer. Conserved key interface residues are shown to be important for MsVps4 assembly, ATPase activity in vitro, ESC...

Some aspects of cooperativity in human hemoglobin.

Some Properties of Crystalline Guinea Pig Hemoglobin

1. Guinea pig hemoglobin crystals are shown to be readily permeable to ferricyanide and hydrosulfite, indicating the presence of interstices between the protein molecules of the crystal. 2. The assumptions of closest hexagonal packing and of spherical molecules of HbO(2) lead to a crystal lattice having interstices between the molecules which represent 25 per cent by volume of the crystal. Thes...

Potassium Channels Some Assembly Required

(Shi et al., 1996, and references therein). In the heart Many types of channels and receptors are expressed and the ear, a single-spanning transmembrane protein, in the nervous system, contributing to the complex and minK, coassembles with KvLQT1 tetramers to form a diverse functional repertoires of neurons. Regulation of delayed rectifier that plays an essential role in repolartranscription an...

Rotavirus genome replication: Some assembly required

1 Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, Virginia, United States of America, 2 Translational Biology, Medicine, and Health Graduate Program, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, United States of America, 3 Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virgin...